Federal Regulations


  • Research Terms and Conditions - Prior Approval Matrix

    This matrix is provided as an at-a-glance summary of whether a particular action under a federal award requires the prior approval of the sponsoring agency. Please note that any of the authorities may be over-ridden by a special term or condition of the award.

  • Office of Management and Budget (OMB) Uniform Guidance (2 C.F.R. Part 200)

    This is a regulation that streamlines and consolidates longstanding government requirements (e.g. OMB Circulars A-21, A-110 and A-133) for recipients of federal awards. The Uniform Guidance became effective for new and continuation awards issued on or after December 26, 2014. It regulates direct and indirect costs associated with sponsored projects and sets forth requirements for audits and sub-recipient monitoring. It also establishes standards for internal controls, accounting, cost-sharing, procurement and property management.

  • 45CFR46 - Protection of Human Subjects

    This section of the Code of Federal Regulation provides safeguards and protection of human subjects used in research. This policy applies to all research involving human subjects conducted, supported or otherwise subject to regulation of any federal department or agency. Other than certain exempt categories, research involving human subjects is subject to review by an institutional committee operating in accordance with the requirements of the policy.

  • Public Health Service Policy on Humane Care and Use of Laboratory Animals

    The Public Health Service (PHS) Policy on Humane Care and Use of Laboratory Animals sets forth the requirements that are applicable to all research, research training, biological testing, and related activities involving animals that are supported or conducted by agencies of the PHS. The Office for Protection from Research Risks (OPRR) at the National Institutes of Health is responsible for the general administration and coordination of the Policy.

  • National Science Foundation Proposal and Award Policies and Procedures Guide (PAPPG)

    The PAPPG is a compendium of basic NSF policies and procedures for use by the grantee community. Its coverage includes the NSF proposal and award processes, from  proposal preparation and submission, to award issuance and administration, through closeout. 

  • NIH Grants Policy Statement

    The National Institutes of Health Grants Policy Statement (NIHGPS) is intended to make available to NIH recipients, in a single document, the policy requirements that serve as the terms and conditions of NIH grant awards. This document also is designed to be useful to those interested in NIH grants by providing information about NIH, its organization, its staff, and its grants process.