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Understanding Mechanisms and Outcomes of Trained Immunity (R01 Clinical Trial Not Allowed)

3 months 1 week ago
Funding Opportunity PAR-24-112 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support research that improves understanding of basic mechanisms and biomarkers of trained immunity (i.e., innate immune memory), plus the functional implications of trained immunity, related to 1) immune system development and function, 2) immunity to vaccines or natural infections, or 3) allergic diseases, autoimmunity, or rejection of organ/tissue/cell transplantation.

Evaluation and Coordinating Center for the AHRQ/PCORI Learning Health System Embedded Scientist Training and Research Centers (U18)

3 months 1 week ago
Funding Opportunity RFA-HS-24-002 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to seek applications for an Evaluation and Coordinating Center to support the AHRQ and PCORI Learning Health System Embedded Scientist Training and Research Centers (P30) (LHS E-STaR) funded under RFA-HS-23-001. The goals of the Evaluation and Coordinating Center are to facilitate coordination of activities among and between recipients; facilitate dissemination, implementation, and uptake of LHS E-STaR outputs to ensure broad public use for health system improvement; and conduct a multi-year mixed-method formative and summative evaluation of the LHS E-STaR Centers.

Novel Approaches for Radiation Biodosimetry Assays and Devices Development (U01 Clinical Trial Not Allowed)

3 months 1 week ago
Funding Opportunity RFA-AI-24-003 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to support radiation research at all stages of development for the identification of biomarkers of injury and the development of assays or devices for the purpose of triage, including assessing absorbed dose or predicting health outcomes of acute or delayed injuries resulting from radiation exposure during a public health emergency. This NOFO will support the development of these approaches, with the goal of future regulatory approval.

Understanding Mechanisms and Outcomes of Trained Immunity (R21 Clinical Trial Not Allowed)

3 months 1 week ago
Funding Opportunity PAR-24-111 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to support research that improves understanding of basic mechanisms and biomarkers of trained immunity (i.e., innate immune memory), plus the functional implications of trained immunity, related to 1) immune system development and function, 2) immunity to vaccines or natural infections, or 3) allergic diseases, autoimmunity, or rejection of organ/tissue/cell transplantation.

Transformative Research to Address Health Disparities and Advance Health Equity (U01 Clinical Trial Optional)

3 months 1 week ago
Funding Opportunity RFA-NR-24-004 from the NIH Guide for Grants and Contracts. The Transformative Research to Address Health Disparities and Advance Health Equity initiative is soliciting applications to support unusually innovative intervention research addressing social determinants of health (SDOH) which, if successful, would have a major impact on preventing, reducing, or eliminating health disparities and advancing health equity. Projects should clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact on advancing NIHs commitment to addressing SDOH to accelerate progress in improving health for all. Preliminary data are not required for this initiative.

Clinical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)

3 months 1 week ago
Funding Opportunity PAR-24-096 from the NIH Guide for Grants and Contracts. The purpose of this Program Announcement (PAR) is to enable clinical validation of strong candidate biomarkers for neurological diseases and conditions. Specifically, the goal of this PAR is to enable the rigorous validation of biomarker measurements within the clinical population of interest to establish the positive and negative predictive values of the candidate biomarker consistent with FDA guidelines. This PAR assumes that 1) a candidate biomarker has already been identified, 2) detection method technology has already been developed and analytically validated, and 3) the research and/or clinical need and potential context of use has been identified.

Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders(U01 Clinical Trial Optional)

3 months 1 week ago
Funding Opportunity PAR-24-095 from the NIH Guide for Grants and Contracts. (Reissue PAR-21-056) The purpose of this Program Announcement (PAR) is to enable analytical validation of strong candidate biomarkers for neurological diseases and conditions. Specifically, the goal of this PAR is to enable the rigorous validation of analytical methods for biomarker measurements, including evaluation of the detection method, its performance characteristics, and the optimal conditions that will generate reproducibility and accuracy consistent with FDA guidelines. This PAR assumes that 1) a candidate biomarker has already been identified, 2) detection method technology has already been developed, and 3) the research and/or clinical need and potential context of use has been identified.
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