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Safety and Efficacy of Amyloid-Beta Directed Antibody Therapy in Mild Cognitive Impairment and Dementia with Evidence of Lewy Body Dementia and Amyloid-Beta Pathology (U01 - Clinical Trial Required)

12 hours 15 minutes ago
Funding Opportunity RFA-NS-25-010 from the NIH Guide for Grants and Contracts. This RFA is soliciting applications proposing placebo-controlled, clinical trials to determine the efficacy and safety of FDA approved monoclonal antibody therapies directed against amyloid compared to placebo in diverse "mixed dementia" populations with a focus on Lewy Body Dementias (LBD). In this NOFO the mixed-etiology dementias (MED) that are of interest and that are in scope are cognitive impairment and dementia cases positive for 1) canonical Alzheimers pathology biomarkers (for example, amyloid deposition assessed using positron emission tomography and/or low cerebrospinal fluid amyloid beta 42 combined with elevated phosphorylated tau; and 2) a clinical LBD diagnosis, i.e. Parkinsons disease dementia (PDD) and/or dementia with Lewy bodies (DLB). Bayesian approaches with response adaptive randomization to examine specific subgroups are encouraged. Successful applications will be powered to determine efficacy in diverse populations representative of the distribution of the disease in the United States by sex, race/ethnicity, and geographic distribution. Applications must include elements of patient and community engagement that are incorporated into all stages of program development and at all levels of the organizational structure.

SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed)

12 hours 16 minutes ago
Funding Opportunity RFA-ES-24-003 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to further the development of Technology-Enhanced Training Products for the health and safety training of hazardous materials (HAZMAT) workers; waste treatment personnel; skilled support personnel associated with an emergency/disaster; emergency responders in biological hazard response, infectious disease response, and medical waste cleanup; emergency responders in disasters; and worker resiliency training. Technology-enhanced training products as defined by the Worker Training Program (WTP) include, but are not limited to, supporting training through various venues such as online training, mobile device training, virtual reality, and serious gaming. These advanced technologies complement all phases of training that can enhance, supplement, improve, and provide health and safety training for hazardous materials workers. These products must complement the goals and objectives of the WTP. The major objective of the NIEHS WTP is to prevent work related harm by training workers in how best to protect themselves and their communities from exposure to hazardous materials. The financial support for this initiative comes directly from NIEHS Worker Education and Training Branch SBIR funds.

NIDCR Dual Degree Dentist Scientist Predoctoral to Postdoctoral Transition Award (F99/K00 Independent Clinical Trial Not Allowed)

14 hours 4 minutes ago
Funding Opportunity PAR-25-021 from the NIH Guide for Grants and Contracts. The purpose of the NIDCR Dual Degree Dentist Scientist Predoctoral to Postdoctoral Transition Award (F99/K00) is to provide support and mentorship to outstanding students enrolled in integrated dual degree dental (DDS/DMD) and PhD programs during the transition from predoctoral student to postdoctoral scholar. This phased award program will facilitate completion of predoctoral dual degree dentist scientist training (F99) and progression to mentored postdoctoral positions in dental, oral and craniofacial research (K00). It is anticipated that successful completion of this phased award program will enhance dual degree dentist scientists' research career trajectories.

HAZMAT Training at DOE Nuclear Weapons Complex (UH4 Clinical Trial Not Allowed)

1 day 22 hours ago
Funding Opportunity RFA-ES-24-002 from the NIH Guide for Grants and Contracts. NIEHS invites applications for cooperative agreements to support the development of model programs for the training and education of workers engaged in activities related to hazardous materials and waste generation, removal, containment, transportation and emergency response within the Department of Energy (DOE) nuclear weapons complex. The aim of this funding opportunity is to prevent work-related harm through safety and health training. The training programs consist of information and practical exercises with the objective of raising the knowledge of workers in protecting themselves and the community from being exposed to hazardous materials encountered during hazardous waste operations; facility decommissioning and decontamination; hazardous materials transportation; environmental restoration of contaminated facilities; or chemical emergency response. Currently, tens of thousands of DOE employees are required to complete safety and health training. The goal of this training is to help reduce the risk of workers being exposed during work activities to hazardous materials and hazardous waste products. The NIEHS/DOE Nuclear Worker Training Program enhances training capabilities at these sites.
6 hours 47 minutes ago
Weekly Funding Opportunities and Policy Notices from the National Institutes of Health.
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