Notice NOT-CA-25-013 from the NIH Guide for Grants and Contracts

Notice NOT-CA-25-019 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-25-157 from the NIH Guide for Grants and Contracts. The National Center for Advancing Translational Sciences (NCATS) invites applications for the Awards Supporting Cutting-Edge Technologies for Translational Science (ASCETTS) Notice of Funding Opportunity (NOFO) to foster investigator-initiated development of highly innovative technologies to address barriers, limitations, or bottlenecks in translational science particularly for therapeutic development. This program will support the early-stage proof of concept, high-risk and potentially high-reward studies for feasibility and exploratory technology development, which can transform or significantly improve the efficiency of therapeutic development to achieve NCATS ultimate goals - more treatments to all people more quickly. The research proposed should be for the development of technology that can break new ground or extend present technology toward new directions or novel applications. With this initiative, we expect to support the development and/or prototyping of new technologies that will lead to improved efficiency in the therapeutic development pipeline.

Funding Opportunity PAR-25-045 from the NIH Guide for Grants and Contracts. The goal of this funding opportunity announcement is to support meritorious research projects that involve secondary data analyses of existing oral or craniofacial database resources, or that develop needed statistical methodology for analyzing existing dental, oral or craniofacial databases.

Notice NOT-HD-24-044 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-25-224 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications that employ integrative experimental and analytical approaches engaging basic and translational/clinical research aimed at developing a comprehensive understanding of the impact of sex differences on the trajectories of brain aging and disease, phenotypes of AD and AD-related dementias (ADRD) risk, individualized prevention, and responsiveness to pharmacologic and non-pharmacologic interventions. To this end, the central goal of this initiative is to develop robust research programs that will explore how genes, environment, and host factors such as hormonal status (gonadal and brain-derived) interact at various levels of biologic complexity (i.e., cell, tissue, organs/organ systems, and populations) to produce heterogeneous phenotypes of disease risk and responsiveness to prevention/therapy in AD/ADRD.

Funding Opportunity PAR-25-156 from the NIH Guide for Grants and Contracts. The purpose of the High Impact Specialized Innovation Programs (SIPs) is to support the development and demonstration of unique hub capabilities, research platforms and/or resources to address in a timely manner critical gap areas and/or roadblocks in clinical and translational science at awarded UM1 Clinical and Translational Science Awards (CTSA) Program Hubs (PAR-24-272). Successful programs supported through this funding opportunity are expected to lay a strong foundation for future adoption and/or dissemination of capabilities to additional CTSA Program Hubs.

Funding Opportunity PAR-25-196 from the NIH Guide for Grants and Contracts. The National Center for Advancing Translational Sciences (NCATS) will award Institutional Research Career Development (K12) programs through the Clinical and Translational Science Awards (CTSA). The purpose of this Notice of Funding Opportunity (NOFO) is to encourage institutions to propose creative and innovative institutional research career development programs designed to prepare an outstanding heterogeneous pool of promising later stage postdoctoral fellows and junior faculty scholars who have made a commitment to independent clinical and translational science research careers (i.e., tenure-track or equivalent faculty positions)to facilitate their timely career advancementand continued engagement in research (i.e., sectors including academia, industry, nonprofit and government).

Funding Opportunity RFA-RM-24-010 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to establish Comprehensive NAMs Technology Development Centers to support NIH Common Funds Complement Animal Research In Experimentation (Complement-ARIE) program. The Complement-ARIE program will accelerate the development, standardization, validation, and use of human-based New Approach Methodologies (NAMs). Complement-ARIE will significantly advance understanding of human health and disease by providing a range of mature and/or validated and standardized biomedical research models. The goal of the Comprehensive NAMs Technology Development Centers is to stimulate the development of combinatorial NAMs to support scientific areas of need, with emphasis on increased biological complexity and throughput, innovative combinatorial approaches, and data sharing according to FAIR principles. Developing these NAMs will require multi-disciplinary expertise in disease research, personalized medicine, screening therapeutics for safety and efficacy, and regulatory science.

Funding Opportunity PAR-25-309 from the NIH Guide for Grants and Contracts. This PAR seeks applications from eligible Small Business Concerns (SBCs) for the development of informatics tools with commercial potential to facilitate uptake and scientific use of the human pangenome reference being developed and maintained by the NHGRI Human Genome Reference Program (HGRP). This PAR specifically calls for innovative Phase I STTR applications from SBCs to demonstrate proof of principle or viability of informatics tools for use of the human pangenome. Emphasis will be on the development of tools to advance compelling use cases that are relevant to different broad sectors of the genomics community, e.g., clinical, population, and functional genomics.

Funding Opportunity PAR-25-308 from the NIH Guide for Grants and Contracts. This PAR seeks applications from eligible Small Business Concerns (SBCs) for the development of informatics tools with commercial potential to facilitate uptake and scientific use of the human pangenome reference being developed and maintained by the NHGRI Human Genome Reference Program (HGRP). This PAR specifically calls for innovative Phase I SBIR applications from SBCs to demonstrate proof of principle or viability of informatics tools for use of the human pangenome. Emphasis will be on the development of tools to advance compelling use cases that are relevant to different broad sectors of the genomics community, e.g., clinical, population, and functional genomics.

Funding Opportunity RFA-AG-25-001 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites applications that aim to develop Common Data Elements (CDEs) for NIA-funded studies on Alzheimers disease (AD) and AD-Related Dementias (ADRD) using Real-World Data (RWD) from electronic health records and claims data from Centers for Medicare and Medicaid Services (CMS). The CDEs will foster data harmonization and interoperability across and among NIA studies that involve disparate and unaligned data fields and RWD. By reducing the efforts required for data harmonization in using studies and RWD for cross-sectional and longitudinal analysis, this NOFO may enable researchers to utilize studies data and RWD more efficiently and produce real-world evidence (RWE) in a timely manner with longitudinal data from NIA-funded studies and RWD.

Funding Opportunity RFA-AG-25-015 from the NIH Guide for Grants and Contracts. The purpose of this NOFO is to invite applications for the Coordination Center for the Alzheimers Disease Sequencing Project (ADSP) consortium. The ADSP Coordination Center will provide leadership and technical expertise in all aspects of ADSP research. The ADSP Coordination Center will lead and coordinate cross-consortium functions, including effective communication, collaboration, outreach, dissemination, training, and coordination across the components of the ADSP. In addition, the ADSP Coordination Center will be the main conduit for collaboration with NIH and NIA funded programs and the global research community in the genetics and genomics of Alzheimers disease and Alzheimers disease-related dementias (AD/ADRD).

Funding Opportunity PAR-24-289 from the NIH Guide for Grants and Contracts. This Ancillary Studies to Ongoing Clinical Projects (R01 Clinical Trial Not Allowed) PAR, a re-issue of PAR-23-025, was re-issued as a result of the Simplifying Review of Research Project Grant Applications [link: https://grants.nih.gov/policy-and-compliance/policy-topics/peer-review/simplifying-review]. The Simplified Review changes in Section V are the only changes that have been made. All other aspects of this funding opportunity remain the same.

Notice NOT-OD-25-044 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-24-287 from the NIH Guide for Grants and Contracts. This Limited Competition: Small Grant Program for NIAMS K01, K08, K23, and K25 Recipients (R03), a re-issue of PAR-22-119, was re-issued as a result of the Simplifying Review of Research Project Grant Applications [link: https://grants.nih.gov/policy-and-compliance/policy-topics/peer-review/simplifying-review]. The Simplified Review changes in Section V are the only changes that have been made. All other aspects of this funding opportunity remain the same.

Funding Opportunity PAR-25-230 from the NIH Guide for Grants and Contracts. This Ancillary Studies to Ongoing Clinical Projects (R21 Clinical Trial Not Allowed) PAR, a re-issue of PAR-23-026, was re-issued as a result of the Simplifying Review of Research Project Grant Applications [link: https://grants.nih.gov/policy-and-compliance/policy-topics/peer-review/simplifying-review]. The Simplified Review changes in Section V are the only changes that have been made. All other aspects of this funding opportunity remain the same.

Funding Opportunity PAR-25-197 from the NIH Guide for Grants and Contracts. The NIH Research Education Program (R25) supports research education activities in the mission areas of the NIH. The overarching goal of this R25 program is to support educational activities that complement and/or enhance the training of a workforce to meet the nations biomedical, behavioral and clinical research needs.

Funding Opportunity PAR-25-330 from the NIH Guide for Grants and Contracts. The purpose of this notice of funding opportunity (NOFO) is to support research to define the impact of defective HIV proviruses on mechanisms of HIV persistence and pathogenesis during antiretroviral treatment and their potential deleterious effects on HIV cure strategies and interference with HIV-specific molecular assays.

Notice NOT-OD-25-028 from the NIH Guide for Grants and Contracts