Funding Opportunity RFA-AI-25-013 from the NIH Guide for Grants and Contracts. The goal of this notice of funding opportunity (NOFO) is to continue to provide operations support to the National Biocontainment Laboratories at the University of Texas Medical Branch (UTMB) in Galveston, Texas and Boston University in Boston, Massachusetts. Operations support is provided in the following areas: facility maintenance and operations; biosecurity; environmental health and safety regulations and requirements; regulatory compliance; and specialized research support services. The NBLs serve as a national resource for efforts in conducting pre-clinical and laboratory (in vitro and in vivo) research and testing on hazardous biological agents in support of NIAIDs biodefense and emerging infectious diseases research efforts. Additionally, in times of a national biodefense or emerging infectious disease (EID) emergency, the NBLs may be expected to rapidly realign their activities to assist response efforts within the US under the direction of NIAID.

Funding Opportunity PAR-25-439 from the NIH Guide for Grants and Contracts. The purpose of this initiative is to support the development of innovative research centers to foster nursing-led programs that promote community-partnered research to address persistent health challenges. Center applications developed in response to this RFA should propose strategies to strengthen the research infrastructure by establishing or expanding centralized research resources in School or College of Nursing (SON/CON), developing and enhancing nurse-led interdisciplinary teams, and building expertise in community-partnered research through conducting pilot research that applies NINR's research lenses. Center strategies should be informed by NINRs mission and should meaningfully engage the community throughout all activities.

Funding Opportunity RFA-DK-26-315 from the NIH Guide for Grants and Contracts. This notice of funding opportunity (NOFO) invites applications designed to examine the efficacy and clinical effectiveness of multimodality digital health technology approaches to the remote management of diabetes.

Funding Opportunity RFA-MH-26-195 from the NIH Guide for Grants and Contracts. The objective of this NOFO is to provide evidence for the optimal treatment of ADHD in adults, given its relatively recent acceptance as a formal diagnostic category. While stimulant drugs offer the advantages of rapid onset of action and history of efficacy, the risk of adverse effects, dependence, misuse, and diversion, along with recent medication shortages, underscore the importance of studying evidence-based complementary and alternative approaches when indicated. Clinical trials testing non-stimulant medications, psychosocial interventions, and device-based approaches, sequentially or in combination, to augment or replace stimulants in situations where stimulant monotherapy is insufficiently effective, difficult to tolerate, or undesirable, in the acute and post-acute treatment of ADHD in adults, or in preventing the transition of ADHD symptoms from adolescence to adulthood, will be supported by this NOFO.

Notice NOT-OD-25-153 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DA-27-004 from the NIH Guide for Grants and Contracts. The Theories, Models and Methods (TMM) initiative will support the development of computational tools for understanding dynamic brain circuits that are made broadly accessible to the greater research community. This program supports applications focused on tool building and dissemination in the domain of theories about neural circuit mechanisms, models of circuit structure and function, and/or computational methods of analysis spanning across scales from neurons to behavior. The development of novel theories, computational models and methods for understanding brain function will help characterize fundamental principles of brain function and organization, characterize cellular and circuit-level neural computations over time in different regions, and understand how interactions of multiple brain circuits enable flexible behaviors and contribute to brain-wide neural dynamics. These tools will be critical for developing treatments such as closed loop systems for brain disorders including Parkinsons disease and major depressive disorder.

Funding Opportunity PAR-25-445 from the NIH Guide for Grants and Contracts. The National Institute on Deafness and Other Communication Disorders (NIDCD) invites applications for Clinical Research Center Grants designed to advance the diagnosis, prevention, treatment, and amelioration of human sensory and communication disorders. For this announcement, Clinical Research is defined as research involving individuals with a sensory and/or communication disorder, or data/tissues from individuals with a sensory and/or communication disorder. Examples of such research include but are not limited to, studies of the prevention, pathogenesis, pathophysiology, diagnosis, treatment, management or epidemiology of a disease or disorder of hearing, balance, smell, taste, voice, speech, or language. Although the intent is that all the research will involve individuals with sensory and/or communication disorders or data/tissues from individuals with sensory and/or communication disorders, when the clinical research goal(s) warrant(s) limited departures from this intent, alternatives (e.g., non-human research, human subjects without a sensory or communication disorder, human at risk for a sensory and/or communication disorder) are possible with appropriate and strong scientific justification and in consultation with NIDCD staff. Applications may propose a low-risk clinical trial but are not required to (optional). Non-responsive applications will not be reviewed. Prospective applicants are strongly encouraged to read this funding opportunity carefully and communicate with the scientific/research contact listed at the end of this award as early as possible to discuss their application plans.

Notice NOT-TR-26-005 from the NIH Guide for Grants and Contracts

Notice NOT-TR-26-004 from the NIH Guide for Grants and Contracts

Notice NOT-OD-25-155 from the NIH Guide for Grants and Contracts

Notice NOT-HL-25-031 from the NIH Guide for Grants and Contracts

Notice NOT-OD-25-154 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-AG-26-007 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites Cooperative Agreement (U24) applications for the National Institute on Aging (NIA) Artificial Intelligence and Technology Collaboratory (AITC) Coordinating Center (AITCC). The AITC Program promotes the development and implementation of artificial intelligence approaches and technology through research projects for aging and AD/ADRD research. The central functions of the AITCC are to (1) serve as a hub for the AITC Program and facilitate and coordinate activities across the AITC Program, (2) centralize and lead key stakeholder engagement activities across the AITC Program, and (3) enhance the scientific impact and reach of the AITC Program by actively disseminating information about the program and attracting new researchers from across the country to participate in program activities and resources.

Funding Opportunity RFA-AG-26-006 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invites Center Core (P30) applications for the National Institute on Aging (NIA) Artificial Intelligence and Technology Collaboratories (AITC) program. The AITC Program promotes the development and implementation of artificial intelligence approaches and technology through research projects for aging and AD/ADRD research. All applications should propose strategies for addressing ethical challenges surrounding artificial intelligence and technologydevelopment and implementation, and to employ, when possible, best practices established in the fields of aging and AD/ADRD.

Funding Opportunity PAR-25-446 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.

Funding Opportunity RFA-AG-26-025 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) invitesapplications for the Claude D. Pepper Older Americans Independence Centers (OAICs) award. The goal of the OAIC program is to establishcenters of excellence in geriatrics research and research education to increase scientific knowledge leading to better ways to maintain or restore independence in older persons. OAIC awards are designed to develop or strengthen programs that focus on, and sustain progress in, a key area of aging research related to the mission of the OAIC program.

Notice NOT-AT-25-008 from the NIH Guide for Grants and Contracts

Notice NOT-ES-25-006 from the NIH Guide for Grants and Contracts

Notice NOT-AR-25-015 from the NIH Guide for Grants and Contracts

Notice NOT-OD-25-149 from the NIH Guide for Grants and Contracts