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Scheduling Analysis and Throughput of Macromolecular Solutions

Background

Tulane University is actively seeking commercial entities tofurther develop and commercializea novel device for scheduling the analytical testing and throughput of macromolecular solutions based on light scattering measurements of one or more time dependent macromolecular solution characteristics.

Applications

The aggregation process of proteins in solution is complex and depends on many factors. Attempts to regulate aggregate content in biologic drugs and to develop methods and standard materials for characterizing aggregates are ongoing, as the formation of aggregates may detract from the therapeutic value of biologic drugs in many ways. Standard best practices call for filtration of medicines prior to administration, which can result in the filtering of the actual drug components themselves along with any aggregates or particles, limiting the effectiveness of the drug.The present invention encompasses a device, method, and system for scheduling the analytic testing and throughput of macromolecular solutions based on light scattering measurements of one or more time dependent macromolecular solution characteristics. Operations that may be performed on the macromolecular solution samples may include, but are not limited to, quantitative or qualitative analytical testing of the solution, removing themacromolecular solution sample from the monitoring reservoir coupled to the light scattering detection instrument, replacing the macromolecular solution sample to a sample testing device, and transferring the macromolecular solution sample to a storage reservoir.

Inventors

Intellectual Property

Available For

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