Notice NOT-OD-25-041 from the NIH Guide for Grants and Contracts

Funding Opportunity PAR-25-251 from the NIH Guide for Grants and Contracts. The purpose of the NIAID Career Transition Award program is to assist postdoctoral fellows' transition to positions of assistant professor or equivalent and initiate a successful biomedical career as an independent research scientist.

Funding Opportunity RFA-RM-24-012 from the NIH Guide for Grants and Contracts. The purpose of the Advancing Non-Invasive Optical Imaging Approaches for Biological Systems initiative is to overcome the problem of light scattering in biological systems. Current optical imaging techniques that are non-invasive and allow rapid assessment of tissue function and structure suffer from strong light scattering within biological tissues, limiting the penetration depth and resolution. This funding opportunity encourages development of next-generation non-invasive or minimally-invasive optical imaging techniques to overcome these issues and to allow deeper imaging of biological systems with high spatial and temporal resolution.

Funding Opportunity PAR-25-215 from the NIH Guide for Grants and Contracts. The objective of the NIH Career Transition Award (K22) is to provide support to outstanding basic or clinical investigators to develop their independent research skills through a two phase program: an initial period involving an intramural appointment at the NIH and a final period of support at an extramural institution. This NINDS K22 is specifically designed to facilitate the transition of NINDS intramural neurologist- and neurosurgeon-scientists to independent, academic faculty positions that support clinician-scientists to engage in independently funded scientific research as well as clinical activities.

Funding Opportunity PAR-25-216 from the NIH Guide for Grants and Contracts. The objective of the NIH Career Transition Award (K22) is to provide support to outstanding basic or clinical investigators to develop their independent research skills through a two phase program: an initial period involving an intramural appointment at the NIH and a final period of support at an extramural institution. This NINDS K22 is specifically designed to facilitate the transition of NINDS intramural neurologist- and neurosurgeon-scientists to independent, academic faculty positions that support clinician-scientists to engage in independently funded scientific research as well as clinical activities.

Funding Opportunity PAR-24-320 from the NIH Guide for Grants and Contracts. The purpose of the NCI Mentored Clinical Scientist Career Development Award (K08) program is to prepare individuals for careers that have a significant impact on the health-related research needs of the nation. This program represents the continuation of a long-standing NIH program that provides support and protected time to individuals with a clinical doctoral degree for an intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research. The NCI-sponsored K08 award is specifically designed to promote career development of clinical scientists from backgrounds that have been shown to be nationally underrepresented in health-related science and for those who are committed to a career in basic biomedical, behavioral or translational cancer research, including research on cancer health disparities. The expectation is that through this sustained period of research career development and training, awardees will develop enhanced research capabilities for cancer research careers and be better prepared to compete for research project grants (e.g. R03, R21, or R01) funding.

Funding Opportunity PAR-24-318 from the NIH Guide for Grants and Contracts. The purpose of the NCI Transition Career Development Award to Promote Diversity is to assist postdoctoral fellows or individuals in equivalent positions to transition to positions of assistant professor or equivalent and initiate a successful biomedical career as an independent research scientist.To this end, the Diversity Training Branch (DTB), within the Center to Reduce Cancer Health Disparities (CRCHD) (http://crchd.cancer.gov/) invites applications from research scientists in postdoctoral positions or equivalent who are from backgrounds nationally underrepresented in biomedical, behavioral, clinical, and/or social sciences. This award will provide "protected time" through salary and research support for 3 years beginning at the time when the candidate starts a tenure-track faculty position.

Funding Opportunity PAR-24-317 from the NIH Guide for Grants and Contracts. The purpose of the NCI Transition Career Development Award to Promote Diversity (K22) is to assist postdoctoral fellows or individuals in equivalent positions to transition to positions of assistant professor or equivalent and initiate a successful biomedical career as an independent research scientist

Funding Opportunity PAR-24-319 from the NIH Guide for Grants and Contracts. The purpose of the NCI Mentored Clinical Scientist Career Development Award (K08) program is to prepare individuals for careers that have a significant impact on the health-related research needs of the nation. This program represents the continuation of a long-standing NIH program that provides support and protected time to individuals with a clinical doctoral degree for an intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research. The NCI-sponsored K08 award is specifically designed to promote career development of clinical scientists from backgrounds that have been shown to be nationally underrepresented in health-related science and for those who are committed to a career in basic biomedical, behavioral or translational cancer research, including research on cancer health disparities. The expectation is that through this sustained period of research career development and training, awardees will develop enhanced research capabilities for cancer research careers and be better prepared to compete for research project grants (e.g. R03, R21, or R01) funding.

Notice NOT-OD-25-037 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-ES-25-003 from the NIH Guide for Grants and Contracts. This Notice of Funding Opportunity (NOFO) is intended to support novel environmental health research in which an unpredictable event or policy change provides a limited window of opportunity to collect human biological samples or environmental exposure data. The primary motivation of the NOFO is to understand the consequences of natural and human-made disasters, emerging environmental public health threats, and policy changes in the U.S. and abroad. A distinguishing feature of an appropriate study is the need for rapid review and funding, substantially shorter than the typical NIH grant review/award cycle, for the research question to be addressed and swiftly implemented. The shortened timeframe will be achieved by more frequent application due dates and expediting peer review, council concurrence and award issuance. The entire cycle, from submission to award, is expected to be within 4-6 months.

Funding Opportunity RFA-AG-24-049 from the NIH Guide for Grants and Contracts. This NOFO invites applications that apply existing or newly developed artificial intelligence and machine learning methods (AI/ML) to various aspects of drug discovery and preclinical drug development to accelerate the identification, optimization, and selection of preclinical drug candidates for the treatment and prevention of Alzheimers disease (AD) and AD-related dementias ADRD and increase their likelihood of success during clinical drug development.This program will also create advanced open-source analytical tools that will be made available to researchers in academia and biotech/pharma for more effective prosecution of AD/ADRD drug discovery campaigns for novel targets.

Funding Opportunity PAR-25-188 from the NIH Guide for Grants and Contracts. The purpose of this Notice of Funding Opportunity (NOFO) is to encourage UG3/UH3 phased cooperative agreement research applications to plan and implement behavioral and social intervention clinical trials. Studies appropriate for this announcement include clinical trials to develop and test behavior change interventions related to dental, oral, or craniofacial conditions. Awards made under this FOA will initially support a milestone-driven planning phase (UG3) for up to 2 years, with possible transition to a clinical trial implementation phase (UH3) of up to five years. Only UG3 projects that have met the scientific milestones and feasibility requirements may transition to the UH3 phase. The UG3/UH3 application must be submitted as a single application, following the instructions described in this FOA. The UG3 phase will permit both scientific and operational planning activities. Scientific planning activities include small-scale data collection to assess the feasibility and/or acceptability of a planned behavioral or social intervention and associated study procedures (e.g., acceptability of study content or mode of delivery; feasibility of proposed data collection procedures; preliminary testing of intervention training and fidelity monitoring procedures). Operational planning activities include, at a minimum, development of: the final clinical protocol; the intervention manual or equivalent; the data management system and other tools for data and quality management, safety and operational oversight plans; recruitment and retention strategies; and other essential documents. The UH3 phase will support the conduct of investigator-initiated intervention research at all stages, from early mechanistic research and intervention development (e.g., Stages 0/ I) through implementation and cost-effectiveness research (Stages IV/V).

Notice NOT-MH-25-105 from the NIH Guide for Grants and Contracts

Notice NOT-CA-25-015 from the NIH Guide for Grants and Contracts

Notice NOT-CA-25-014 from the NIH Guide for Grants and Contracts

Notice NOT-OD-25-021 from the NIH Guide for Grants and Contracts

Notice NOT-AG-24-085 from the NIH Guide for Grants and Contracts

Notice NOT-AG-24-084 from the NIH Guide for Grants and Contracts

Funding Opportunity RFA-DA-26-004 from the NIH Guide for Grants and Contracts. Pre-exposure prophylaxis, also known as PrEP, is a safe, highly effective medication for preventing transmission of HIV from sex or injection drug use. Despite PrEPs high efficacy and its availability for over a decade, the awareness, uptake, and adherence of PrEP, especially among people who use substances remain suboptimal. The goal of this concept is to support research to examine and address systemic and structural factors that impede or facilitate the PrEP awareness, uptake, and adherence, among people who use substances. Projects will develop, implement, and evaluate effective strategies that meet the needs of people who use substances to improve the PrEP care continuum.