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Weekly Funding Opportunities and Policy Notices from the National Institutes of Health.
Updated: 16 hours 57 min ago

Innovative Mental Health Services Research Not Involving Clinical Trials (R01 Clinical Trials Not Allowed)

Fri, 01/06/2023 - 03:17
Funding Opportunity PAR-23-095 from the NIH Guide for Grants and Contracts. The purpose of this funding announcement is to encourage innovative research that will inform and support the delivery of high-quality, continuously improving mental health services to benefit the greatest number of individuals with, or at risk for developing, a mental illness. This announcement invites applications for non-clinical trial R01-level projects that address NIMH strategic priorities for mental health services research.

Initiation of a Mental Health Family Navigator Model to Promote Early Access, Engagement and Coordination of Needed Mental Health Services for Children and Adolescents (R01 Clinical Trial Required)

Fri, 01/06/2023 - 02:57
Funding Opportunity PAR-23-094 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage research applications to develop and test the effectiveness and implementation of family navigator models designed to promote early access, engagement and coordination of mental health treatment and services for children and adolescents who are experiencing early symptoms of mental health problems. For the purposes of this FOA, NIMH defines a family navigator model as a health care professional or paraprofessional whose role is to deploy a set of strategies designed to rapidly engage youth and families in needed treatment and services, work closely with the family and other involved treatment and service providers to optimize care and monitor the trajectory of mental health symptoms and outcomes over time. Applicants are encouraged to develop and test the navigator models ability to promote early access, engagement and coordination of mental health treatment and services for children and adolescents as soon as symptoms are detected. Of interest are navigator models that coordinate needed care strategies, determine the personalized match to the level of needed service amount, frequency and intensity, and harness novel technologies to track and monitor the trajectory of clinical, functional and behavioral progress toward achieving intended services outcomes. This FOA is published in parallel to a companion R34

Mood and Psychosis Symptoms during the Menopause Transition (R01 Clinical Trial Optional)

Fri, 01/06/2023 - 02:37
Funding Opportunity PAR-23-097 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to advance translational research to better understand the emergence and worsening of mood and psychotic disorders (e.g., perimenopausal depression (PMD), generalized anxiety disorder, bipolar disorder and schizophrenia) during the menopause transition (MT) in an effort to identity targets for future development of novel treatment interventions. This funding opportunity aims to advance novel and innovative translational research to better comprehend the underlying neurobiological and behavioral mechanisms of mood and psychosis disorders and related symptoms during MT. This funding opportunity also encourages interdisciplinary researchers to collaborate on studies of mood and psychosis during the MT. Aspects of mood and psychosis disorders that are of interest include: classic depressive symptoms in combination with menopause symptoms (e.g., hot flashes, night sweats, sleep disturbance) and psychological challenges, the role of reproductive steroids in the regulation of mood and behavior during the MT, diagnosis of mood and psychosis symptoms at menopausal stage, investigation of co-occurring psychiatric and menopause symptoms, appreciation of psychosocial factors common in midlife, and differential diagnoses. Review criteria will focus on the comprehensiveness of the neurobiology and mechanisms of action underlying mood and psychosis symptoms and hypothesis-driven work.

Effectiveness of Implementing Sustainable Evidence-Based Mental Health Practices in Low-Resource Settings to Achieve Mental Health Equity for Traditionally Underserved Populations (R01 Clinical Trial Optional)

Fri, 01/06/2023 - 01:34
Funding Opportunity PAR-23-092 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages studies that develop and test the effectiveness of strategies for implementation and sustainable delivery of evidence-based mental health treatments and services to improve mental health outcomes for underserved populations in under-resourced settings in the United States. Studies should identify and use innovative approaches to remediate barriers to provision, receipt, and/or benefit from evidence-based practices (EBPs) and generate new information about factors integral to achieving equity in mental health outcomes for underserved populations. Research generating new information about factors causing/reducing disparities are strongly encouraged, including due consideration of the needs of individuals across the life span.

Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01 Clinical Trial Optional)

Fri, 01/06/2023 - 01:07
Funding Opportunity PAR-23-093 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage applications to pursue invasive neural recording studies focused on mental health-relevant questions. Invasive neural recordings provide an unparalleled window into the human brain to explore the neural circuitry and neural dynamics underlying complex moods, emotions, cognitive functions, and behaviors with high spatial and temporal resolution. Additionally, the ability to stimulate, via the same electrodes, allows for direct causal tests by modulating network dynamics. This funding opportunity aims to target a gap in the scientific knowledge of neural circuit function related to mental health disorders. Researchers should target specific questions suited to invasive recording modalities that have high translational potential. Development of new technologies and therapies are outside the scope of this FOA.

Salary Limitation on AHRQ FY2023 Grants, Cooperative Agreements, and Contracts

Fri, 01/06/2023 - 00:38
Notice NOT-HS-23-005 from the NIH Guide for Grants and Contracts

Building in vivo Preclinical Assays of Circuit Engagement for Application in Therapeutic Development (R01 Clinical Trial Not Allowed)

Fri, 01/06/2023 - 00:03
Funding Opportunity PAR-23-091 from the NIH Guide for Grants and Contracts. The overall goal of this Funding Opportunity Announcement (FOA) is to identify, in animals, in vivo neurophysiological and behavioral measures for use as assays in the early screening phase of treatment development. The FOA will support efforts to optimize and evaluate measures of neurophysiological and behavioral processes that may serve as surrogate markers of neural processes of clinical interest based on available knowledge of the neurobiology of mental illnesses. The screening assays thus developed from this FOA are expected to build upon systems neurobiology and clinical neuroscience to enhance the scientific value of preclinical animal data contributing to a therapeutic development pipeline by assessing the impact of therapeutic targets and treatment candidates on neurobiological mechanisms of clinical relevance to mental illnesses.

Notice of Special Interest (NOSI): Fundamental Science Research on the Neural Circuits Underlying Sensory Processing

Thu, 01/05/2023 - 09:23
Notice NOT-DC-23-001 from the NIH Guide for Grants and Contracts

Pilot and Feasibility Trials on the Integration of Social and Medical Care for Type 1 Diabetes Mellitus (R01 Clinical Trial Required)

Thu, 01/05/2023 - 02:44
Funding Opportunity RFA-DK-22-028 from the NIH Guide for Grants and Contracts. The purpose of this NIDDK Funding Opportunity Announcement (FOA) is to support pilot and feasibility trials to test pragmatic interventions that include screening for adverse social determinants of health (SDoH) and referring or providing resource service linkages for social services within the healthcare setting for individuals living with type 1 diabetes. The pilot trials will determine 1) feasibility of screening for social risks and implementing referral service linkages (e.g., connecting persons in need to appropriate transportation, housing, food, etc. resources) within the context of a healthcare encounter, and 2) preliminary signals of the interventions impact on both the social risk(s) and type 1 diabetes (T1D) specific outcomes such as glycemic control. The overarching goal of this FOA is to stimulate collaborations between healthcare systems, community-based organizations, and social service entities for testing and advancing effective interventions which integrate social care and medical care to reduce health disparities in T1D.

BRAIN Initiative: Transformative Brain Non-invasive Imaging Technology Development (UG3/UH3 Clinical Trial Not Allowed)

Thu, 01/05/2023 - 02:35
Funding Opportunity RFA-EB-22-003 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits applications for team-centric development and validation of innovative non-invasive imaging technologies that could have a transformative impact on the study of brain function/connectivity. Applications are expected to turn a novel concept into a functional prototype using this phased grant mechanism. The feasibility should be established by the end of its first phase and serve as a foundation for the transition to its second phase. Fully developing the technology into a functional prototype and validating it by in-vivo animal or human function/connectivity imaging are anticipated in the second phase. The research plan should provide a realistic timeline and tangible milestones to support the proposed development effort. Awards will be integrated into the BRAIN Non-Invasive Imaging Consortium, as a coordinated network on brain function/connectivity imaging.

HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed)

Tue, 01/03/2023 - 09:24
Funding Opportunity PAR-23-069 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to facilitate the transition of previously funded SBIR and STTR Phase II and Phase IIB projects in pain management to the commercialization stage by providing additional assistance for private partnering activities through the Commercialization Readiness Pilot (CRP) program. Specifically, this FOA supports the addition of entrepreneurial expertise into small business leadership teams along with supporting partnering activities to aid in commercialization through private third-party funding or partnership with industry.

Research Centers in Minority Institutions (RCMI) (U54 Clinical Trial Optional)

Tue, 01/03/2023 - 09:09
Funding Opportunity RFA-MD-23-001 from the NIH Guide for Grants and Contracts. The purpose of the Research Centers in Minority Institutions (RCMI) Program is to expand the national capacity for research in the health sciences by providing cooperative agreement support to institutions that offer doctorate degrees in the health professions or in a health-related science and have a historical and current commitment to educating underrepresented students, and for institutions that deliver health care, and provide clinical services to medically underserved communities.

Request for Information (RFI): Inviting Input Regarding NIDCDs Support of Non-Invasive Imaging in Humans

Tue, 01/03/2023 - 08:35
Notice NOT-DC-23-004 from the NIH Guide for Grants and Contracts

Notice of Special Interest (NOSI): Administrative Supplement to Support Global Cancer Stigma Research

Thu, 12/29/2022 - 09:16
Notice NOT-CA-23-025 from the NIH Guide for Grants and Contracts

Bidirectional Influences Between Adolescent Social Media Use and Mental Health (R21 Clinical Trial Optional)

Thu, 12/29/2022 - 09:10
Funding Opportunity RFA-MH-23-116 from the NIH Guide for Grants and Contracts. This funding opportunity announcement (FOA) focuses on understanding bidirectional relationships between social media use and adolescent mental health, psychiatric symptoms, and risk or resilience for psychopathology. For the purposes of this FOA, social media are defined as internet-based communication platforms and applications that enable interactions between users by sharing or consuming information. The FOA focuses on adolescents (broadly defined here as 10-20 years of age), who have increasing access to social media and greater autonomy in their use of digital platforms. No effectiveness/efficacy trials will be accepted.

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