Compositions for the prevention and treatment of HIV with mesenchymal stem cells

Background

Tulane University is actively seeking commercial entities to further develop and commercialize compositions to treat HIV using mesenchymal stem cells that express HIV antiviral fusion inhibitors.

Applications

MSCs expressing antiviral fusion inhibitors may be used to prevent HIV infection pre-exposure or post-exposure. MSC compositions may be used to treat HIV infection alone or in combination with anti-retroviral therapy. Multiple antiviral fusion inhibitors may be used in the MSC compositions, including peptide inhibitors and neutralizing antibodies. AdvantagesMSC compositions provide long-term, continuous expression of HIV inhibitors. Side effects associated with currently-available HIV inhibitors are avoided. MSC compositions may use autologous or allogeneic stem cells.